Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure

Golam M. Uddin, Liyan Zhang, Saumya Shah, +14

Cardiovascular Diabetology

Cardiac MuscleHeart FailureCardiac Bcaa AccumulationCardiac Insulin ResistanceMetabolic Remodeling +17

AP39, a mitochondria-targeting hydrogen sulfide (H₂S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling

Qutuba G. Karwi, Julia Bornbaum, Kerstin Boengler, +5

British Journal of Pharmacology

Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction

Qutuba G. Karwi, Liyan Zhang, Cory S. Wagg, +7

Cardiovascular Diabetology

Ketones can become the major fuel source for the heart but do not increase cardiac efficiency

Kim L. Ho, Qutuba G. Karwi, Cory S. Wagg, +6

Cardiovascular Research

Adropin regulates cardiac energy metabolism and improves cardiac function and efficiency

Tariq Altamimi, Su Gao, Qutuba G. Karwi, +5

Metabolism

Cardiac FunctionCardiomyopathyCardiac MuscleMolecular PhysiologyCardiovascular Disease +10

Mitochondrial fatty acid oxidation is the major source of cardiac adenosine triphosphate production in heart failure with preserved ejection fraction

Qiuyu Sun, Berna Güven, Cory S. Wagg, +13

Cardiovascular Research

Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137

Qutuba G. Karwi, Matthew Whiteman, Mark E. Wood, +2

Pharmacological Research

Heart FailurePharmacological PostconditioningCardiogenic ShockCardiovascular DiseaseMedicine +8

Insulin directly stimulates mitochondrial glucose oxidation in the heart

Qutuba G. Karwi, Cory S. Wagg, Tariq Altamimi, +5

Cardiovascular Diabetology

Influence of Molecular Weight and Degree of Deacetylation of Low Molecular Weight Chitosan on the Bioactivity of Oral Insulin Preparations

Nidal A. Qinna, Qutuba G. Karwi, Nawzat Al-Jbour, +5

Marine Drugs

EngineeringGlycobiologyPolysaccharideBiomedical EngineeringInsulin Signaling +14

Weight loss enhances cardiac energy metabolism and function in heart failure associated with obesity

Qutuba G. Karwi, Liyan Zhang, Tariq Altamimi, +9

Diabetes Obesity and Metabolism