Yoshinari Miyata

Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

Matthew T. N. Yarnall, Eleonora Ioannidi, Cian Schmitt-Ulms et al. · Nature Biotechnology · 2022 · 429 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

Umesh K. Jinwal, Yoshinari Miyata, John Koren et al. · Journal of Neuroscience · 2009 · 229 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

Aikaterini Rousaki, Yoshinari Miyata, Umesh K. Jinwal et al. · Journal of Molecular Biology · 2011 · 193 citations

Life Sciences, Medicinal Chemistry, Pharmacology +16

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

Adrienne M. Wang, Yoshinari Miyata, Susan Klinedinst et al. · Nature Chemical Biology · 2012 · 186 citations · Full text

Life Sciences, Neurobiology, Neuroscience +14

Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

Yoshinari Miyata, Xiaokai Li, Hsiu-Fang Lee et al. · ACS Chemical Neuroscience · 2013 · 133 citations · Full text

Medicine, Neuroscience, Pharmacology +17