Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences

Elisé P. Wright, Henry A. Day, Ali Mohamed Ibrahim, +6

Scientific Reports

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

Sara M. Elkashef, Simon J. Allison, Maria Sadiq, +5

Scientific Reports

Colon Cancer–Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins

Sandra Travica, Klaus Pors, Paul M. Loadman, +7

Clinical Cancer Research

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid

Agnese Chiara Pippione, Irene Maria Carnovale, Davide Bonanni, +13

European Journal of Medicinal Chemistry

Bioisosteric ScaffoldMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +10

Synthesis of DNA-Directed Pyrrolidinyl and Piperidinyl Confined Alkylating Chloroalkylaminoanthraquinones:  Potential for Development of Tumor-Selective <i>N</i>-Oxides

Klaus Pors, Steven D. Shnyder, Paul Teesdale‐Spittle, +4

Journal of Medicinal Chemistry

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

Klaus Pors, Paul M. Loadman, Steven D. Shnyder, +7

Chemical Communications

Biological ActivityMedicinal ChemistryDrug TargetBiochemistryNatural Sciences +11

Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder

Mark Sutherland, Jason H. Gill, Paul M. Loadman, +9

Molecular Cancer Therapeutics

Duocarmycin Analogue RationalizedAntitumor ActivityCytochrome P450 1A1Ict2700 AdministrationCancer Biology +14

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach

Agnese Chiara Pippione, Alessandro Giraudo, Davide Bonanni, +10

European Journal of Medicinal Chemistry

Medicinal ChemistryAldo-keto ReductaseBiochemistryHydroxytriazole DerivativesMedicine +7

Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity

Helen M. Sheldrake, Sandra Travica, Inger Johansson, +12

Journal of Medicinal Chemistry

Pharmaceutical ScienceDrug TargetMolecular BiologyDuocarmycin BioprecursorsHigh Frequency +17

Synthesis and Biological Evaluation of Colchicine B-Ring Analogues Tethered with Halogenated Benzyl Moieties

Laura Cosentino, Mariano Redondo‐Horcajo, Ying Zhao, +12

Journal of Medicinal Chemistry

Halogenated Benzyl MoietiesCombinatorial ChemistrySubstituted Benzyl HalidesOrganic ChemistryChemistry +14