NEC is likely a NETs dependent process and markers of NETosis are predictive of NEC in mice and humans

Deirdre Vincent, Michaela Klinke, Georg Eschenburg, +6

Scientific Reports

ImmunologyNec PathogenesisPathologyCell DeathNec Severity +16

Therapeutic targeting of extracellular DNA improves the outcome of intestinal ischemic reperfusion injury in neonatal rats

Michael Boettcher, Georg Eschenburg, Stefan Mietzsch, +7

Scientific Reports

Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis

Georg Eschenburg, Angelika Eggert, Alexander Schramm, +2

Cancer Research

ApoptosisImmunologyCellular IapCell DeathXiap Protein +14

Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of <i>ETV6-RUNX1</i> negative B precursor acute lymphoblastic leukemia

Lena Harder, Georg Eschenburg, Antonia T.L. Zech, +12

The Journal of Experimental Medicine

Degradation of Extracellular DNA by DNase1 Significantly Reduces Testicular Damage After Testicular Torsion in Rats

Michael Boettcher, Dennis Meier, Miguel Jiménez-Alcázar, +10

Urology

ChromatinGenome InstabilityDna DamageGerm CellCell Division +13

Gut inflammation and expression of ICC in a fetal lamb model of fetoscopic intervention for gastroschisis

Thomas Krebs, Michael Boettcher, Hansjörg Schäfer, +12

Surgical Endoscopy

Animal PhysiologyFetal Lamb ModelFunctional Gastrointestinal DisorderAnimal SciencePathogenesis +10

Modulation of Thrombosis Significantly Reduces Testicular Damage after Testicular Torsion in Rats: Anti-Thrombotic Treatment and Testicular Torsion

Michael Boettcher, Tobias A. Fuchs, Hansjörg Schäfer, +8

Urology

SpermatogenesisInfertilityAndrologyAnti-thrombotic TreatmentTesticular Torsion +6

Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice

Alexander Stermann, Nicole Huebener, Diana Seidel, +6

Cancer Immunology Immunotherapy

VaccinationNeuro-oncologyVaccine DevelopmentGliomaDna Vaccination +6

Smac mimetic LCL161 supports neuroblastoma chemotherapy in a drug class-dependent manner and synergistically interacts with ALK inhibitor TAE684 in cells with ALK mutation F1174L

Safiullah Najem, Doerte Langemann, Birgit Appl, +4

Oncotarget

Tumor BiologyNeuroblastoma ChemotherapyAlk Mutation F1174lSmac Mimetic Lcl161Vinca Alkaloids +13

Sensitization of neuroblastoma for vincristine-induced apoptosis by Smac mimetic LCL161 is attended by G2 cell cycle arrest but is independent of NFκB, RIP1 and TNF-α

Doerte Langemann, Magdalena Trochimiuk, Birgit Appl, +3

Oncotarget

ApoptosisImmunologyVincristine-induced ApoptosisCell DeathCell Death Mechanisms +14