Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.

Hartmut Engelmann, Helmut Holtmann, Cord Brakebusch, +6

Journal of Biological Chemistry

ImmunologyImmune RegulationPathologyCell DeathImmunologic Mechanism +15

Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

Y. Nophar, O. Kemper, Cord Brakebusch, +5

The EMBO Journal

InflammationSoluble FormImmunologyPathologyCell Surface +6

Sensitization and desensitization to lethal effects of tumor necrosis factor and IL-1.

David Wallach, Helmut Holtmann, Hartmut Engelmann, +1

The Journal of Immunology

Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor.

Cord Brakebusch, Y. Nophar, O. Kemper, +2

The EMBO Journal

InflammationCytokineSignal TransductionSignaling PathwayMedicine +10

Poliovirus 2A Protease Induces Apoptotic Cell Death

Dan Goldstaub, Alessandra Gradi, Zippi Bercovitch, +5

Molecular and Cellular Biology

Viral ReplicationProtein ExpressionNatural SciencesPathogenesisViral Pathogenesis +12

Soluble and cell surface receptors for tumor necrosis factor

H. Engelmann, D. Aderka, Y. Nophar, +4

InflammationCytokineTumor Necrosis FactorAnti-inflammatoryImmunology +5

Selective decrease in cell surface expression and mRNA level of the 55-kDa tumor necrosis factor receptor during differentiation of HL-60 cells into macrophage-like but not granulocyte-like cells

Reinhard Winzen, Donald F. H. Wallach, Hartmut Engelmann, +5

The Journal of Immunology

Dominance of resistance to the cytocidal effect of tumor necrosis factor in heterokaryons formed by fusion of resistant and sensitive cells.

Y. Nophar, Helmut Holtmann, Raphael Ber, +1

The Journal of Immunology

ApoptosisImmunologyInnate Immune SystemCell DeathPathology +16

The gene for the type 1 tumor necrosis factor receptor (TNF-R1) is localized on band 12p13

Josette Derr�, Oliver Kemper, Dorra Chérif, +3

Human Genetics

InflammationType 1CytokineSignal TransductionSignaling Pathway +9