Anne M. Strimpler

Design, synthesis, and kinetic evaluation of a unique class of elastase inhibitors, the peptidyl .alpha.-ketobenzoxazoles, and the x-ray crystal structure of the covalent complex between porcine pancreatic elastase and Ac-Ala-Pro-Val-2-benzoxazole

Philip D. Edwards, Edgar F. Meyer, J. Vijayalakshmi et al. · Journal of the American Chemical Society · 1992 · 144 citations

Unique Class, Inhibitory Activity, Medicinal Chemistry +15

Mechanism of slow-binding inhibition of human leukocyte elastase by trifluoromethyl ketones

Ross L. Stein, Anne M. Strimpler, Phillip D. Edwards et al. · Biochemistry · 1987 · 102 citations

Human Leukocyte Elastase, Hemiketal Intermediate, Chemical Biology +19

Orally Active Trifluoromethyl Ketone Inhibitors of Human Leukocyte Elastase

Chris A. Veale, Peter R Bernstein, Claudia Bohnert et al. · Journal of Medicinal Chemistry · 1997 · 70 citations · Full text

Medicinal Chemistry, Oral Bioavailability, Pharmaceutical Science +13

Biologic Characterization of ICI 200,880 and ICI 200,355, Novel Inhibitors of Human Neutrophil Elastase

Joseph C. Williams, Ronald C. Falcone, Cathy Knee et al. · American Review of Respiratory Disease · 1991 · 66 citations

Pharmaceutical Science, Immunology, Pharmacotherapy +16

Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements

Ross L. Stein, Anne M. Strimpler, Hitoshi Hori et al. · Biochemistry · 1987 · 64 citations