Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

Takayuki Kondo, Masashi Asai, Kayoko Tsukita, +40

Cell stem cell

Neurodegenerative DiseasesIntracellular AβAlzheimer's DiseaseStressMedicine +7

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

Naohiro Egawa, Shiho Kitaoka, Kayoko Tsukita, +35

Science Translational Medicine

Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor

Nobukazu Miyamoto, Takakuni Maki, Akihiro Shindo, +8

Journal of Neuroscience

The Endoplasmic Reticulum Stress Sensor, ATF6α, Protects against Neurotoxin-induced Dopaminergic Neuronal Death

Naohiro Egawa, Keisuke Yamamoto, Haruhisa Inoue, +4

Journal of Biological Chemistry

ApoptosisCell DeathEr StressSynaptic SignalingRedox Biology +20

Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke

Akihiro Shindo, Takakuni Maki, Emiri T. Mandeville, +12

Stroke

Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs

Michiko Yoshida, Shiho Kitaoka, Naohiro Egawa, +11

Stem Cell Reports

Neuromuscular JunctionSystems BiologySpinal Cord InjuryMuscle FunctionSkeletal Muscle +6

TDP-43 stabilises the processing intermediates of mitochondrial transcripts

Keiichi Izumikawa, Yuko Nobe, Harunori Yoshikawa, +14

Scientific Reports

Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial

Keiko Imamura, Yuishin Izumi, Makiko Nagai, +18

EClinicalMedicine

Induced pluripotent stem cell–based Drug Repurposing for Amyotrophic lateral sclerosis Medicine (iDReAM) study: protocol for a phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis patients

Keiko Imamura, Yuishin Izumi, Haruhiko Banno, +18

BMJ Open

Modeling Drug‐Induced Neuropathy Using Human iPSCs for Predictive Toxicology

Reiko Ohara, Keiko Imamura, F. Morii, +7

Clinical Pharmacology & Therapeutics