Synthetically defined glycoprotein vaccines: current status and future directions

Roberto Adamo, Alberto Nilo, Bastien Castagner, +3

Chemical Science

VaccinationProtein CarrierBiochemistryNatural SciencesImmunology +12

Tyrosine-Directed Conjugation of Large Glycans to Proteins via Copper-Free Click Chemistry

Alberto Nilo, Martin Allan, Barbara Brogioni, +9

Bioconjugate Chemistry

Bioorganic ChemistryEngineeringGlycobiologyMolecular BiologyPolysaccharide +19

Anti-Group B <i>Streptococcus</i> Glycan-Conjugate Vaccines Using Pilus Protein GBS80 As Carrier and Antigen: Comparing Lysine and Tyrosine-directed Conjugation

Alberto Nilo, Laura Morelli, Irene Passalacqua, +12

ACS Chemical Biology

ImmunologyGlycobiologyImmunodominanceConjugation SiteVaccine Target +15

Exploring the Effect of Conjugation Site and Chemistry on the Immunogenicity of an anti-Group B <i>Streptococcus</i> Glycoconjugate Vaccine Based on GBS67 Pilus Protein and Type V Polysaccharide

Alberto Nilo, Irene Passalacqua, Monica Fabbrini, +11

Bioconjugate Chemistry

Bioorganic ChemistrySite Selective CouplingGlycobiologyImmunologyMolecular Biology +24

Immunoactivity of Protein Conjugates of Carba Analogues from <i>Neisseria meningitidis</i> A Capsular Polysaccharide

Qi Gao, Marta Tontini, Giulia Brogioni, +9

ACS Chemical Biology

Protein Carrier Crm197Microbial PathogensImmunologyGlycobiologyPeptide Science +18

Synthesis and immunological evaluation of protein conjugates of <i>Neisseria meningitidis</i> X capsular polysaccharide fragments

Laura Morelli, Damiano Cancogni, Marta Tontini, +7

Beilstein Journal of Organic Chemistry

ImmunologyGlycobiologyMolecular BiologyPolysaccharideSynthetic Immunology +14

Recombinant Clostridium difficile Toxin Fragments as Carrier Protein for PSII Surface Polysaccharide Preserve Their Neutralizing Activity

Maria Rosaria Romano, Rosanna Leuzzi, Emilia Cappelletti, +7

Toxins

ToxinologyImmunologyPsii GlycoconjugatesInfection ControlAntimicrobial Resistance +16

High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers

Jonathan T. Sullivan, Chidananda Sulli, Alberto Nilo, +7

Journal of Virology

Investigating the immunodominance of carbohydrate antigens in a bivalent unimolecular glycoconjugate vaccine against serogroup A and C meningococcal disease

Roberto Adamo, Alberto Nilo, Carole Harfouche, +11

Glycoconjugate Journal

VaccinationSerogroup AVaccine DevelopmentC Meningococcal DiseaseVaccine Target +6