Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, +40

Nature

Radiation OncologyCancer ImmunosurveillanceT CellsMedicineT-regulatory Cell +9

Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies

Barbara Mair, Jelena Tomić, Sanna N. Masud, +15

Cell Reports

GeneticsAdult Stem CellGenomic MechanismHpsc FitnessStem Cell Biology +18

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximilian Billmann, +21

Nature Metabolism

Metabolic SyndromeSystematic MappingLipid MetabolismBiochemistryMedicine +8

Context-dependent regulation of ferroptosis sensitivity

Leslie Magtanong, Grace D. Mueller, Kevin J. Williams, +10

Cell chemical biology

Signal TransductionBiochemistryMetalloproteinPhysiologyCytoskeleton +6

Identifying cell receptors for the nanoparticle protein corona using genome screens

Wayne Ngo, Jamie L. Y. Wu, Zachary P. Lin, +8

Nature Chemical Biology

Nanoparticle Protein CoronaNanomedicineSignal TransductionProtein CoronaEngineering +11

A cohesin traffic pattern genetically linked to gene regulation

Anne-Laure Valton, Sergey V. Venev, Barbara Mair, +7

Nature Structural & Molecular Biology

Cohesin Traffic PatternGeneticsGenomic MechanismGenetic MechanismMolecular Genetics +3

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation

Yuqing Feng, Conglei Li, Jessica A. Stewart, +18

Nature

Genome InstabilityImmunologyCell ProliferationAntibody MaturationMedicine +2

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Sylvia Varland, Rui D. Silva, Ine Kjosås, +23

Nature Communications

The pathways for nanoparticle transport across tumour endothelium

Jamie L. Y. Wu, Qin Ji, Colin Blackadar, +11

Nature Nanotechnology

NanoparticlesNanomedicineEngineeringNanoparticle TransportTumor Targeting +3

Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells

Michael Aregger, Megha Chandrashekhar, Amy H.Y. Tong, +2

Methods in molecular biology

Off-target EffectFunctional GenomicsGeneticsGenetic EngineeringGene Editing +5