Understanding the Biological Rationale for the Diversity of Cellulose-directed Carbohydrate-binding Modules in Prokaryotic Enzymes

Anthony W. Blake, Lesley McCartney, J.E. Flint, +4

Journal of Biological Chemistry

GlycobiologyMolecular BiologyPolysaccharideStructure-function Enzyme KineticsWood Component +15

Two common single nucleotide polymorphisms in the gene encoding β‐carotene 15,15′‐monoxygenase alter β‐carotene metabolism in female volunteers

Wing Cheong Leung, Susanne Hessel, Catherine Méplan, +6

The FASEB Journal

Female VolunteersGeneticsGenetic EpidemiologyHuman PolymorphismAlter β‐Carotene Metabolism +14

A Survey of Chemicals for Mutagenic Action on E. coli

M. Demerec, G. Bertani, J.E. Flint

The American Naturalist

E. ColiEngineeringAntimicrobial Resistance GeneBiochemistryThirty-one Chemicals +13

How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity

Fiona Cuskin, J.E. Flint, T.M. Gloster, +8

Proceedings of the National Academy of Sciences

Differential recognition of plant cell walls by microbial xylan-specific carbohydrate-binding modules

Lesley McCartney, Anthony W. Blake, J.E. Flint, +4

Proceedings of the National Academy of Sciences

GlycobiologyMolecular BiologyPolysaccharideXylan-binding CbmsDifferential Recognition +15

Understanding the Structural Basis for Substrate and Inhibitor Recognition in Eukaryotic GH11 Xylanases

Maria Vardakou, Claire Dumon, James W. Murray, +6

Journal of Molecular Biology

BiochemistryProtein AssemblyNatural SciencesStructural BioinformaticsBiomolecular Structure Prediction +10

Engineering Hyperthermostability into a GH11 Xylanase Is Mediated by Subtle Changes to Protein Structure

Claire Dumon, Alexander Varvak, M. A. Wall, +13

Journal of Biological Chemistry

Protein AssemblyMolecular BiologyGh11 Xylanase IsProtein SynthesisProtein Folding +15

Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function

Cédric Montanier, Alicia Lammerts van Bueren, Claire Dumon, +18

Proceedings of the National Academy of Sciences

Understanding How Diverse β-Mannanases Recognize Heterogeneous Substrates

Louise E. Tailford, V.M.-A. Ducros, J.E. Flint, +9

Biochemistry

Crystal StructureSuch HeterogeneityBioorganic ChemistryEngineeringBiochemistry +13

Structural dissection and high-throughput screening of mannosylglycerate synthase

J.E. Flint, Edward J. Taylor, Min Yang, +7

Nature Structural & Molecular Biology

BiosynthesisEngineeringBiochemistryNatural SciencesEnzyme Catalysis +5