E J Krull

Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy.

Mary K. Danks, Christopher L. Morton, E J Krull et al. · PubMed · 1999 · 97 citations

Chemoprevention Strategy, Pharmacotherapy, Chemical Biology +17

Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase.

Sylvie M. Guichard, Christopher L. Morton, E J Krull et al. · PubMed · 1998 · 36 citations

Rabbit Liver Carboxylesterase, Anticancer Drug Cpt-11, Pharmaceutical Chemistry +16

A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11.

M M Meck, Monika Wierdl, Lars M. Wagner et al. · PubMed · 2001 · 29 citations

Cell-based Drug Delivery, Rabbit Carboxylesterase, Gene Therapies +14

Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies.

Kyoung Jin P. Yoon, E J Krull, Christopher L. Morton et al. · PubMed · 2003 · 15 citations

Human Liver Ce, Drug Target, Camptothecin Prodrug +19

Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC- or N-MYC-regulated protein expression.

Rekha Iyengar, C A Pawlik, E J Krull et al. · PubMed · 2001 · 15 citations

Molecular Regulation, Molecular Biology, C-myc Protein +18