Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

Xin Chen, Wenjuan Li, Junming Ren, +8

Cell Research

Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling

Wanze Chen, Zhenru Zhou, Lisheng Li, +9

Journal of Biological Chemistry

Content-aware generative modeling of graphic design layouts

Xinru Zheng, Xiaotian Qiao, Ying Cao, +1

ACM Transactions on Graphics

Architectural DesignGeometric ModelingGraphic Design LayoutsGenerative SystemGenerative Development +11

Ppm1b negatively regulates necroptosis through dephosphorylating Rip3

Wanze Chen, Jianfeng Wu, Lisheng Li, +15

Nature Cell Biology

Signal TransductionApoptosisCell DeathMedicineCell Biology +2

The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process

Deli Huang, Xinru Zheng, Zi-an Wang, +9

Molecular and Cellular Biology

Mlkl OctamerNecroptosis IsApoptosisMolecular BiologyCell Death +23

Association of the triglyceride-glucose index with all-cause and cardiovascular mortality in patients with cardiometabolic syndrome: a national cohort study

Quanjun Liu, Yeshen Zhang, Shuhua Chen, +12

Cardiovascular Diabetology

D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway

Xingxing Xu, Xiya Shen, Wenjin Feng, +15

Aging

Chemoprevention StrategyApoptosisLamin B1Cell ProliferationGlioma +17

PACS2/CPT1A/DHODH signaling promotes cardiomyocyte ferroptosis in diabetic cardiomyopathy

Hong Xiang, Qi Lyu, Shuhua Chen, +7

Cardiovascular Diabetology

Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum

Yingxin Wang, Fanzhen Yu, Xinru Zheng, +7

Lipids in Health and Disease

Metabolic RemodelingInsulin SignalingObesityMetabolic SyndromeFatty Acid Biosynthesis +18

Design, Synthesis, and Bioevaluation of Novel NLRP3 Inhibitor with IBD Immunotherapy from the Virtual Screen

Ziwen Zhang, Hongyu Wu, Kai Yin, +5

Journal of Medicinal Chemistry