Comparison of Topoisomerase I Inhibition, DNA Damage, and Cytotoxicity of Camptothecin Derivatives Presently in Clinical Trials

Akihiko Tanizawa, A. Fujimori, Yoshihiro Fujimori, +1

JNCI Journal of the National Cancer Institute

bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.

Saori Kamesaki, H Kamesaki, Timothy J. Jorgensen, +3

PubMed

Genome InstabilityParental Ch31 CloneChemoprevention StrategyOncogenic AgentMedicine +13

Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society.

Shinsaku Imashuku, Shigeyoshi Hibi, Toshio Ohara, +21

PubMed

Differential Stabilization of Eukaryotic DNA Topoisomerase I Cleavable Complexes by Camptothecin Derivatives

Akihiko Tanizawa, Kurt W. Kohn, Glenda Kohlhagen, +2

Biochemistry

Chemoprevention StrategyMolecular BiologyCancer BiologyTumor BiologyOncology +17

Distinct Impact of Imatinib on Growth at Prepubertal and Pubertal Ages of Children with Chronic Myeloid Leukemia

Haruko Shima, Mika Tokuyama, Akihiko Tanizawa, +11

The Journal of Pediatrics

Hematological MalignancyChromatinChronic Myeloid LeukemiaDistinct ImpactDevelopmental Biology +9

Transient MR Signal Changes in the Splenium of the Corpus Callosum in Rotavirus Encephalopathy: Value of Diffusion-weighted Imaging

Ritsuyo Kobata, Hirokazu Tsukahara, Akio Nakai, +5

Journal of Computer Assisted Tomography

Medical ImagingNeuroanatomyProton DiffusionResonanceRestricted Diffusion +13

Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance.

Akihiko Tanizawa, R Beitrand, Glenda Kohlhagen, +3

Journal of Biological Chemistry

GeneticsMolecular BiologySingle Point MutationMolecular GeneticsAmino Acid Change +14

RNA synthesis inhibitors alter the subnuclear distribution of DNA topoisomerase I.

Christopher A. Buckwalter, Amy Lin, Akihiko Tanizawa, +3

PubMed

ChromatinNucleic Acid ChemistryBiochemistryChromatin RemodelingNatural Sciences +13

Inhibition of both etoposide-induced DNA fragmentation and activation of poly(ADP-ribose) synthesis by zinc ion

Tsunehiro Shimizu, Masaru Kubota, Akihiko Tanizawa, +5

Biochemical and Biophysical Research Communications

Nucleic Acid ChemistryBioorganic ChemistryBiochemistryEtoposide-induced Dna FragmentationNatural Sciences +6

Biochemical characterization of U937 cells resistant to L-asparaginase: the role of asparagine synthetase.

Yoshimitsu Kiriyama, M. Kubota, Takahiro Takimoto, +4

PubMed