Juliet Lefferts

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Olivier G. de Jong, Daniel E. Murphy, Imre Mäger et al. · Nature Communications · 2020 · 193 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

Gimano D. Amatngalim, Lisa W. Rodenburg, Bente L. Aalbers et al. · Life Science Alliance · 2022 · 51 citations · Full text

Medicine, Cell Biology, Pharmacology +15

CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes

Juliet Lefferts, Marlou C. Bierlaagh, Suzanne Kroes et al. · International Journal of Molecular Sciences · 2023 · 39 citations · Full text

Medicine, Molecular Genetics, Pharmacotherapy +15

OrgaSegment: deep-learning based organoid segmentation to quantify CFTR dependent fluid secretion

Juliet Lefferts, Suzanne Kroes, Matthew B. Smith et al. · Communications Biology · 2024 · 37 citations · Full text

Life Sciences, Bioengineering, Cell Biology +14

A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

Omnia M. Elsharkasy, Charlotte V. Hegeman, Tom A. P. Driedonks et al. · Nature Communications · 2025 · 14 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17