RyRs mediate lead-induced neurodegenerative disorders through calcium signaling pathways

Fankun Zhou, Guihua Du, Jie Xie, +10

The Science of The Total Environment

Neurodegenerative DiseasesDegenerative PathologyNeurologyNeuroscienceNeurodegeneration +4

The Glial Cell-Derived Neurotrophic Factor (GDNF)-responsive Phosphoprotein Landscape Identifies Raptor Phosphorylation Required for Spermatogonial Progenitor Cell Proliferation

Min Wang, Yueshuai Guo, Mei Wang, +10

Molecular & Cellular Proteomics

The effect of lead exposure on brain iron homeostasis and the expression of DMT1/FP1 in the brain in developing and aged rats

Gaochun Zhu, Guangqin Fan, Chang Feng, +9

Toxicology Letters

Lead ExposureBrain DevelopmentIron MetabolismBrain HealthPhysiology +9

Oxidative stress in the neurodegenerative brain following lifetime exposure to lead in rats: Changes in lifespan profiles

Chang Feng, Sisi Liu, Fankun Zhou, +9

Toxicology

Neurodegenerative DiseasesAlzheimer's DiseaseAgingLongevityPhysiology +9

The effect of lead exposure on expression of SIRT1 in the rat hippocampus

Chang Feng, Junwang Gu, Fankun Zhou, +9

Environmental Toxicology and Pharmacology

Rat HippocampusLead ExposureMolecular NeuroscienceMedicinePhysiology +6

Proper timing of a quiescence period in precursor prospermatogonia is required for stem cell pool establishment in the male germline

Guihua Du, Melissa J. Oatley, Nathan C. Law, +3

Development

Insight into the effect of a heavy metal mixture on neurological damage in rats through combined serum metabolomic and brain proteomic analyses

Jie Xie, Fankun Zhou, Lu Ouyang, +12

The Science of The Total Environment

Heavy Metal MixtureOxidative StressSerum MetabolomicToxicologyBrain Injury +14

Lead exposure-induced cognitive impairment through RyR-modulating intracellular calcium signaling in aged rats

Lu Ouyang, Wei Zhang, Guihua Du, +8

Toxicology

Ryr-modulating Intracellular CalciumAlzheimer's DiseaseNeurophysiologyPhysiologyNeuroprotection +7

Cognitive outcomes caused by low-level lead, cadmium, and mercury mixture exposure at distinct phases of brain development

Lu Ouyang, Qi Li, Shaoqi Rao, +7

Food and Chemical Toxicology

NeuropsychologyBrain DevelopmentDevelopmental Cognitive NeurosciencePsychologySocial Sciences +22

mRBPome capture identifies the RNA-binding protein TRIM71, an essential regulator of spermatogonial differentiation

Guihua Du, Xinrui Wang, Mengcheng Luo, +9

Development

SpermatogenesisRna-binding Protein Trim71Rbp Trim71GeneticsMolecular Genetics +18