Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells

Arunasree M. Kalle, Jayasree Badiger, Ali Nakhi, +2

Biochemical and Biophysical Research Communications

Breast OncologyApoptosisBreast Cancer CellsCell DeathBreast Cancer +6

A new route to indoles via in situ desilylation–Sonogashira strategy: identification of novel small molecules as potential anti-tuberculosis agents

Ali Nakhi, Bagineni Prasad, Uppender Reddy, +10

MedChemComm

Situ Desilylation–sonogashira StrategyMedicinal ChemistryBiosynthesisBioorganic ChemistryNovel Indoles +12

AlCl3-mediated hydroarylation–heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest

Ali Nakhi, Sivakumar Archana, Guru Pavan Kumar Seerapu, +5

Chemical Communications

A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53

Ananga Ghosh, Amrita Sengupta, Guru Pavan Kumar Seerapu, +6

Biochemical and Biophysical Research Communications

Chemoprevention StrategyMedicineInduces ApoptosisCell DeathColorectal Cancer +6

Thieno[3,2-c]pyran-4-one based novel small molecules: Their synthesis, crystal structure analysis and in vitro evaluation as potential anticancer agents

Ali Nakhi, Raju Adepu, D. Rambabu, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryCrystal Structure AnalysisNatural SciencesMedicineChemistry +6

Ultrasound assisted synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives: Their in silico assessment as potential ligands for N-protein of SARS-CoV-2

Shaik Shahinshavali, Kazi Amirul Hossain, Abbaraju Venkata Durga Nagendra Kumar, +5

Tetrahedron Letters

Combinatorial ChemistryPotential LigandsSilico AssessmentChemistryHeterocycle Chemistry +3

Sequential coupling/desilylation–coupling/cyclization in a single pot under Pd/C–Cu catalysis: Synthesis of 2-(hetero)aryl indoles

Raja Mohan Rao, Upendar Reddy, Ali Nakhi, +6

Organic & Biomolecular Chemistry

Pyrrolo[2,3-b]quinoxalines as inhibitors of firefly luciferase: Their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay

Ali Nakhi, Md. Shafiqur Rahman, Ravada Kishore, +4

Bioorganic & Medicinal Chemistry Letters

Cu-mediated SynthesisFirefly LuciferaseAntiparasitic AgentMedicineNatural Sciences +6

Transition metal free hydrolysis/cyclization strategy in a single pot: synthesis of fused furo N-heterocycles of pharmacological interest

Ali Nakhi, Md. Shafiqur Rahman, Guru Pavan Kumar Seerapu, +5

Organic & Biomolecular Chemistry

Single PotMedicinal ChemistryBioorganic ChemistryEngineeringBiochemistry +13

Amberlite IR-120H catalyzed MCR: Design, synthesis and crystal structure analysis of 1,8-dioxodecahydroacridines as potential inhibitors of sirtuins

Ali Nakhi, Padaki Srinivas, Md. Shafiqur Rahman, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAmberlite Ir-120hCrystal Structure AnalysisBiochemistryNatural Sciences +6