Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

D.J. Marcotte, Yuting Liu, Robert M. Arduini, +11

Protein Science

SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage

Mohini Jangi, Christina Fleet, Patrick Cullen, +10

Proceedings of the National Academy of Sciences

<i>Cx3cr1-</i>deficient microglia exhibit a premature aging transcriptome

Stefka Gyoneva, Raghavendra Hosur, David Gosselin, +13

Life Science Alliance

Association between changes in gene signatures expression and disease activity among patients with systemic lupus erythematosus

Michelle Petri, Wei Fu, Ann Ranger, +4

BMC Medical Genomics

Organotypic Brain Slice Culture Microglia Exhibit Molecular Similarity to Acutely-Isolated Adult Microglia and Provide a Platform to Study Neuroinflammation

Alex R. D. Delbridge, Dann Huh, Margot Brickelmaier, +16

Frontiers in Cellular Neuroscience

MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response

Kathryn Pellerin, Stephen Rubino, Jeremy C. Burns, +21

Brain

Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms

Melanie S. Brennan, Hiral Patel, Norm Allaire, +8

Antioxidants and Redox Signaling

Small molecule mediated inhibition of <scp>ROR</scp><i>γ</i>‐dependent gene expression and autoimmune disease pathology <i>in vivo</i>

Daliya Banerjee, Linlin Zhao, Lan Wu, +13

Immunology

Adaptive Immune SystemImmunologyImmune RegulationImmunologic MechanismCd4 T Cell Responses +21

Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments

Haiyan Peng, Li Huo, Adam Sheehy, +3

Journal of Neuroimmunology

InflammationProinflammatory Toxic MicroenvironmentsDimethyl Fumarate AltersMedicinePharmacology +5

Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patients

Loubna Chadli, Britt Sotthewes, Kejie Li, +13

Scientific Reports