Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice

Qian Ren, Fan Guo, Sibei Tao, +3

Biomedicine & Pharmacotherapy

Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-β/SMAD3 signaling

Qian Ren, Sibei Tao, Fan Guo, +4

Phytomedicine

InflammationAnti-inflammatoryMedicineChronic Kidney DiseaseImmunology +10

Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis

Rongshuang Huang, Fan Guo, Yanping Li, +4

Phytomedicine

Metabolic SyndromeHepatologyTriptolide AlleviatesLiver PhysiologyHepatic Lipid Metabolism +9

FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury

Letian Yang, Bo Wang, Fan Guo, +7

Signal Transduction and Targeted Therapy

Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis

Bo Wang, Lina Yang, Letian Yang, +4

Acta Pharmacologica Sinica

InflammationFibrosisRenal FunctionFibrotic Kidney DiseaseIron Metabolism +10

Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis

Bo Wang, Jun Xu, Qian Ren, +7

Cell Death and Disease

Inhibition of ACSS2-mediated histone crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence

Lingzhi Li, Ting Xiang, Jingjing Guo, +7

Nature Communications

Fisetin Improves Hyperuricemia-Induced Chronic Kidney Disease via Regulating Gut Microbiota-Mediated Tryptophan Metabolism and Aryl Hydrocarbon Receptor Activation

Qian Ren, Lu Cheng, Fan Guo, +4

Journal of Agricultural and Food Chemistry

InflammationGastrointestinal Peptide HormoneBiochemistryHyperuricemia-induced Ckd MiceMedicine +13

Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy

Jing Pan, Min Shi, Lingzhi Li, +5

Biomedicine & Pharmacotherapy

Renal PathologyRenal InflammationRenal FibrosisHyperuricemic NephropathySevere Mouse Model +15

Anti-Inflammatory Pyranochalcone Derivative Attenuates LPS-Induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Pathway

Min Shi, Xiaoxi Zeng, Fan Guo, +5

Molecules