Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth

Joel Bergman, Karrune Woan, Patricio Perez-Villarroel, +3

Journal of Medicinal Chemistry

Malignant MelanomaCancer BiologyPharmaceutical ChemistryTumor BiologyMolecular Pharmacology +18

Essential role of HDAC6 in the regulation of PD‐L1 in melanoma

Maritza Lienlaf, Patricio Perez-Villarroel, Tessa Knox, +16

Molecular Oncology

Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma

Rana Falahat, Anders Berglund, Ryan M. Putney, +5

Proceedings of the National Academy of Sciences

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells

Fengdong Cheng, Maritza Lienlaf, Patricio Perez-Villarroel, +11

Molecular Immunology

ChromatinTranscriptional RegulationAutoimmune DiseaseChromatin RemodelingImmunology +8

A Novel Role for Histone Deacetylase 6 in the Regulation of the Tolerogenic STAT3/IL-10 Pathway in APCs

Fengdong Cheng, Maritza Lienlaf, Hongwei Wang, +14

The Journal of Immunology

Epigenetic ChangeSelective Hdac6 InhibitorImmunologyImmune RegulationImmunologic Mechanism +26

The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity

David Woods, Karrune Woan, Fengdong Cheng, +9

Melanoma Research

ImmunologyPathologyDermatologyImmunotherapyMelanoma Cells +18

STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity

Rana Falahat, Patricio Perez-Villarroel, Adam W. Mailloux, +4

Cancer Immunology Research

Induction of Tertiary Lymphoid Structures With Antitumor Function by a Lymph Node-Derived Stromal Cell Line

Genyuan Zhu, Satoshi Nemoto, Adam W. Mailloux, +5

Frontiers in Immunology

Epigenetic state determines the in vivo efficacy of STING agonist therapy

Rana Falahat, Anders Berglund, Patricio Perez-Villarroel, +6

Nature Communications

Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology

Eva Sahakian, Jie Chen, John J. Powers, +17

Journal of Leukocyte Biology