Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

Dilshan S. Harischandra, Dharmin Rokad, Matthew L. Neal, +11

Science Signaling

Blinded <scp>RT‐QuIC</scp> Analysis of <scp>α‐Synuclein</scp> Biomarker in Skin Tissue From Parkinson's Disease Patients

Sireesha Manne, Naveen Kondru, Huajun Jin, +3

Movement Disorders

α‐Synuclein Real‐Time Quaking‐Induced Conversion in the Submandibular Glands of Parkinson's Disease Patients

Sireesha Manne, Naveen Kondru, Huajun Jin, +3

Movement Disorders

Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease

Souvarish Sarkar, Hai M. Nguyen, Emir Malovic, +21

Journal of Clinical Investigation

Synaptic TransmissionKinase FynCellular NeurobiologySynaptic SignalingSocial Sciences +22

Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders

Sireesha Manne, Naveen Kondru, Monica Hepker, +6

Journal of Neuroimmune Pharmacology

ImmunologyAggregated α-SynucleinNeurochemical BiomarkersSocial SciencesNeuroinflammation +14

Experimental Transmission of the Chronic Wasting Disease Agent to Swine after Oral or Intracranial Inoculation

S. Jo Moore, M. Heather West Greenlee, Naveen Kondru, +5

Journal of Virology

The AD tau core spontaneously self-assembles and recruits full-length tau to filaments

Yari Carlomagno, Sireesha Manne, Michael DeTure, +14

Cell Reports

Temporal Resolution of Misfolded Prion Protein Transport, Accumulation, Glial Activation, and Neuronal Death in the Retinas of Mice Inoculated with Scrapie

M. Heather West Greenlee, Melissa Lind, Robyn Kokemuller, +6

American Journal Of Pathology

Creutzfeldt-jakob DiseaseCellular NeuroscienceMedicineMice InoculatedPrion Disease +8

Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases

Naveen Kondru, Sireesha Manne, Justin J. Greenlee, +5

Scientific Reports

PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway

Manikandan Samidurai, Bharathi N. Palanisamy, Alejandra Bargues-Carot, +7

Frontiers in Aging Neuroscience