Blinded <scp>RT‐QuIC</scp> Analysis of <scp>α‐Synuclein</scp> Biomarker in Skin Tissue From Parkinson's Disease Patients

Abstract

Our blinded study results clearly demonstrate the feasibility of using skin tissues for clinical diagnosis of PD by detecting pathological αSyn. Moreover, this peripheral biomarker discovery study may have broader translational value in detecting misfolded proteins in skin samples as a longitudinal progression marker. © 2020 International Parkinson and Movement Disorder Society.