Nathan K. Karpowich

ATP Binding to the Motor Domain from an ABC Transporter Drives Formation of a Nucleotide Sandwich Dimer

Paul Smith, Nathan K. Karpowich, Linda Millen et al. · Molecular Cell · 2002 · 767 citations · Full text

Biophysical Modeling, Motor Domain, Biochemistry +9

LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake

Zheng Zhou, Juan Zhen, Nathan K. Karpowich et al. · Science · 2007 · 335 citations · Full text

Antidepressant Desipramine, Psychotropic Medication, Neurotransmitter +17

Crystal Structures of the MJ1267 ATP Binding Cassette Reveal an Induced-Fit Effect at the ATPase Active Site of an ABC Transporter

Nathan K. Karpowich, Oksana Martsinkevich, Linda Millen et al. · Structure · 2001 · 283 citations · Full text

Biochemistry, Natural Sciences, Membrane Transport +11

Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures

Zheng Zhou, Juan Zhen, Nathan K. Karpowich et al. · Nature Structural & Molecular Biology · 2009 · 237 citations · Full text

Molecular Pharmacology, Psychiatry, Medicine +13

Crystal Structures of the BtuF Periplasmic-binding Protein for Vitamin B12 Suggest a Functionally Important Reduction in Protein Mobility upon Ligand Binding

Nathan K. Karpowich, Hector H. Huang, Paul Smith et al. · Journal of Biological Chemistry · 2003 · 161 citations · Full text

Crystal Structure, Vitamin B12 Suggest, Protein Assembly +16