LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake

Zheng Zhou, Juan Zhen, Nathan K. Karpowich, +4

Science

Antidepressant DesipraminePsychotropic MedicationNeurotransmitterPsychopharmacologyMolecular Biology +15

Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures

Zheng Zhou, Juan Zhen, Nathan K. Karpowich, +3

Nature Structural & Molecular Biology

Molecular PharmacologyPsychiatryMedicinePsychotropic MedicationNeurotransmitter +11

Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia

Manju A. Kurian, Juan Zhen, Shuyuan Cheng, +12

Journal of Clinical Investigation

Neurodegenerative DiseasesHomozygous Loss-of-function MutationsDopamine TransporterParkinson DiseaseGenetics +13

Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study

Manju A. Kurian, Yan Li, Juan Zhen, +19

The Lancet Neurology

Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures

Tommy Stödberg, Amy McTague, Arnaud Ruiz, +28

Nature Communications

Kcc2 DysfunctionGeneticsNeurotransmitterNeurotransmissionSynaptic Signaling +16

Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood

Joanne Ng, Juan Zhen, Esther Meyer, +19

Brain

Importance of cholesterol in dopamine transporter function

Kymry T. Jones, Juan Zhen, Maarten E. A. Reith

Journal of Neurochemistry

Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress‐induced apoptosis in a streptozotocin‐induced diabetes rat model

Haitao Yu, Juan Zhen, Yang Yang, +3

Journal of Cellular and Molecular Medicine

Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine

Nianhang Chen, Juan Zhen, Maarten E. A. Reith

Journal of Neurochemistry

Interaction of cocaine‐, benztropine‐, and GBR12909‐like compounds with wild‐type and mutant human dopamine transporters: molecular features that differentially determine antagonist‐binding properties

Kyle C. Schmitt, Juan Zhen, Prashant S. Kharkar, +4

Journal of Neurochemistry