Florian Klammers

Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling

Nicole A. Kratochwil, Christophe Meille, Stephen Fowler et al. · The AAPS Journal · 2017 · 107 citations · Full text

Fatty Liver Disease, Physiologically-based Pharmacokinetic Modeling, Metabolic Syndrome +25

Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction

Kenichi Umehara, Carina Cantrill, Matthias Wittwer et al. · Drug Metabolism and Disposition · 2020 · 37 citations · Full text

In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes

Luca Docci, Florian Klammers, Aynur Ekiciler et al. · The AAPS Journal · 2020 · 28 citations

Metabolic Clearance, Long-term Co-cultured Human, Hepatotoxicity +16

Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human Hepatocytes

Florian Klammers, Andreas Goetschi, Aynur Ekiciler et al. · Drug Metabolism and Disposition · 2022 · 21 citations · Full text

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor

Nicole A. Kratochwil, Miriam Triyatni, Martina B. Mueller et al. · Journal of Pharmacology and Experimental Therapeutics · 2018 · 13 citations · Full text