Sunil Koovakkat

Discovery of <i>N</i>-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1<i>H</i>-imidazol-2-yl)phenoxy]pyridin-4-yl]-<i>N</i>-methylglycine (ZK-807834):  A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa

Gary B. Phillips, Brad O. Buckman, David D. Davey et al. · Journal of Medicinal Chemistry · 1998 · 63 citations · Full text

Pharmaceutical Science, Altmetric Attention Score, Pharmacotherapy +16

Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors

Brad O. Buckman, Raju Mohan, Sunil Koovakkat et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 55 citations · Full text

Biological Activity, Combinatorial Chemistry, Biochemistry +9

Synthesis, Characterization, and Structure−Activity Relationships of Amidine-Substituted (Bis)benzylidene-Cycloketone Olefin Isomers as Potent and Selective Factor Xa Inhibitors

William J. Guilford, Kenneth J. Shaw, Jerry L. Dallas et al. · Journal of Medicinal Chemistry · 1999 · 43 citations · Full text

Combinatorial Chemistry, Organic Chemistry, Chemistry +17

Design, Synthesis, and Activity of 2,6-Diphenoxypyridine-Derived Factor Xa Inhibitors

Gary B. Phillips, David D. Davey, Keith Eagen et al. · Journal of Medicinal Chemistry · 1999 · 37 citations · Full text

Bovine Trypsin, Protein Chemistry, Medicinal Chemistry +13

Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin

Marc Whitlow, Damain O. Arnaiz, Brad O. Buckman et al. · Acta Crystallographica Section D Biological Crystallography · 1999 · 31 citations · Full text

X-ray Crystallography, Protein Assembly, Chemical Biology +16