Naoki Nishimoto

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo

Raja Atreya, Jonas Mudter, Susetta Finotto et al. · Nature Medicine · 2000 · 1.3K citations

Life Sciences, Immunology, Pathology +17

Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease

Kazuyuki Yoshizaki, Tadashi Matsuda, Naoki Nishimoto et al. · Blood · 1989 · 904 citations

Veterinary Medicine, Immunology, Pathology +12

Therapeutic benefit of blocking interleukin‐6 activity with an anti–interleukin‐6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled, dose‐escalation trial

Ernest Choy, David Isenberg, Toby Garrood et al. · Arthritis & Rheumatism · 2002 · 535 citations

Life Sciences, Immunology, Pharmacotherapy +15

Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study

Naoki Nishimoto, N. Miyasaka, Kazuhiko Yamamoto et al. · Annals of the Rheumatic Diseases · 2008 · 337 citations · Full text

Medicine, Clinical Sciences, Pharmacotherapy +17

B cells are generated throughout life in humans

César Núnêz, Naoki Nishimoto, G. Larry Gartland et al. · The Journal of Immunology · 1996 · 175 citations · Full text

Life Sciences, Developmental Biology, Immunology +17