The genomic landscape of response to EGFR blockade in colorectal cancer

Andrea Bertotti, Eniko Papp, Siân Jones, +32

Nature

OncologyGenomic LandscapeMedicinePathologyColorectal Cancer +7

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies

Eugenia R. Zanella, Francesco Galimi, Francesco Sassi, +12

Science Translational Medicine

Tumor BiologyMarginal ResponseStable DiseaseChemoprevention StrategyIgf Inhibitors +12

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Barbara Lupo, Francesco Sassi, Marika Pinnelli, +29

Science Translational Medicine

Tumor BiologyGastrointestinal OncologyPi3k SignalingMedicineMaximal Response +12

The Plasma Membrane Sialidase NEU3 Regulates the Malignancy of Renal Carcinoma Cells by Controlling β1 Integrin Internalization and Recycling

Cristina Tringali, Barbara Lupo, Ilaria Silvestri, +4

Journal of Biological Chemistry

Stem cell mobilization in patients with newly diagnosed multiple myeloma after lenalidomide induction therapy

Federica Cavallo, Giuseppe Milone, Dina Ben‐Yehuda, +20

Leukemia

Hematological MalignancyLenalidomide Induction TherapyOncologyMedicineStem Cell Mobilization +7

Expression of Sialidase Neu2 in Leukemic K562 Cells Induces Apoptosis by Impairing Bcr-Abl/Src Kinases Signaling

Cristina Tringali, Barbara Lupo, Luigi Anastasia, +5

Journal of Biological Chemistry

Mixed-phenotype Acute LeukemiaApoptosisImmunologyCell DeathBcr-abl/src Kinases +15

RETRACTED ARTICLE: Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3

Cristina Tringali, Barbara Lupo, Federica Cirillo, +8

Cell Death and Differentiation

Sialidase NEU4 is involved in glioblastoma stem cell survival

Ilaria Silvestri, Francesca Testa, Roberta Zappasodi, +7

Cell Death and Disease

Stem Cell BiologyCancer BiologyGliomaTumor BiologyNeuro-oncology +15

Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody

Emanuela Pupo, Nadia Ducano, Barbara Lupo, +6

Cancer Research

Chemoprevention StrategyImmunologyPharmacotherapyTumor BiologyReceptor Tyrosine Kinase +17

Phosphoproteomics of patient-derived xenografts identifies targets and markers associated with sensitivity and resistance to EGFR blockade in colorectal cancer

Robin Beekhof, Andrea Bertotti, Franziska Böttger, +16

Science Translational Medicine

Chemoprevention StrategyMedicineReceptor Tyrosine KinasePharmacologyColorectal Cancer +10