Structure and Concentration Changes Affect Characterization of UGT Isoform-Specific Metabolism of Isoflavones

Lan Tang, Rashim Singh, Zhongqiu Liu, +1

Molecular Pharmaceutics

Metabolomic ProfilingSecondary MetaboliteUgt IsoformsBioanalysisMetabolic Pathway Analysis +14

Disposition of Naringenin via Glucuronidation Pathway Is Affected by Compensating Efflux Transporters of Hydrophilic Glucuronides

Haiyan Xu, Kaustubh H. Kulkarni, Rashim Singh, +4

Molecular Pharmaceutics

BiochemistryMedicineLiver PhysiologyEfflux Transporters Mrp2Gastroenterology +11

Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC–MS/MS method: Application to an oral bioavailability study of genistein in mice

Zhen Yang, Wei Zhu, Song Gao, +6

Journal of Pharmaceutical and Biomedical Analysis

BiochemistryMedicinePhysiologyBioanalysisMetabolomic Profiling +8

Identification of the Position of Mono-<i>O</i>-glucuronide of Flavones and Flavonols by Analyzing Shift in Online UV Spectrum (λ_max) Generated from an Online Diode Array Detector

Rashim Singh, Baojian Wu, Lan Tang, +2

Journal of Agricultural and Food Chemistry

Use of Glucuronidation Fingerprinting To Describe and Predict Mono- and Dihydroxyflavone Metabolism by Recombinant UGT Isoforms and Human Intestinal and Liver Microsomes

Lan Tang, Ling Ye, Rashim Singh, +5

Molecular Pharmaceutics

Three-Dimensional Quantitative Structure-Activity Relationship Studies on UGT1A9-Mediated 3-O-Glucuronidation of Natural Flavonols Using a Pharmacophore-Based Comparative Molecular Field Analysis Model

Baojian Wu, John Kenneth Morrow, Rashim Singh, +2

Journal of Pharmacology and Experimental Therapeutics

Uridine Diphosphate Glucuronosyltransferase Isoform-Dependent Regiospecificity of Glucuronidation of Flavonoids

Rashim Singh, Baojian Wu, Lan Tang, +1

Journal of Agricultural and Food Chemistry

BiosynthesisBiotransformationBiochemistryMost Ugt IsoformsMedicine +9

SULT1A3-Mediated Regiospecific 7-O-Sulfation of Flavonoids in Caco-2 Cells Can Be Explained by the Relevant Molecular Docking Studies

Shengnan Meng, Baojian Wu, Rashim Singh, +4

Molecular Pharmaceutics

Nutraceutical IngredientGlycobiologyChemical BiologyPolyphenolicsOxidative Stress +17

Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement <i>Magnolia officinalis</i> Extract for Prevention against Oral Carcinoma

Dinh Bui, Li Li, Taijun Yin, +5

Journal of Agricultural and Food Chemistry

Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats

Yifan Tu, Lu Wang, Yi Rong, +5

eLife