CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function

Ya Guo, Quan Xu, Daniele Canzio, +16

Cell

Transcriptional RegulationNatural SciencesGeneticsMolecular BiologyGene Editing +8

Neutrophil hitchhiking for drug delivery to the bone marrow

Zhenyu Luo, Yichao Lu, Yingying Shi, +13

Nature Nanotechnology

Bone Marrow FailureGranulocyteImmunologyHematologyBone Marrow +3

CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2

Lingdong Meng, Yihan Zhang, Pengfei Wu, +11

Molecular Cancer

Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy

Mengshi Jiang, Xiang Li, Junlei Zhang, +10

ACS Nano

Linc01232 promotes the metastasis of pancreatic cancer by suppressing the ubiquitin-mediated degradation of HNRNPA2B1 and activating the A-Raf-induced MAPK/ERK signaling pathway

Lingdong Meng, Guodong Shi, Wanli Ge, +11

Cancer Letters

Ubiquitin-mediated DegradationTumor BiologyPancreatic CancerMedicineA-raf-induced Mapk/erk +6

Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice

Li Fan, Yichao Lu, Xiulian Shen, +3

eLife

Arginine Supplementation Targeting Tumor-Killing Immune Cells Reconstructs the Tumor Microenvironment and Enhances the Antitumor Immune Response

Junlei Zhang, Sijie Wang, Xuemeng Guo, +11

ACS Nano

Antitumor Immune ResponseCancer ImmunosurveillanceTumor GrowthImmunologyTumor Immunity +11

MicroRNA-222 Promotes the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Targeting P27 and TIMP3

Ying Xu, Yihua Bei, Shutong Shen, +4

Cellular Physiology and Biochemistry

Endoplasmic reticulum-targeted inhibition of CYP2E1 with vitamin E nanoemulsions alleviates hepatocyte oxidative stress and reverses alcoholic liver disease

Yingying Shi, Yu Liu, Sijie Wang, +8

Biomaterials

Alcoholic Liver DiseaseHepatologyBiochemistryVitamin E NanoemulsionsMedicine +13

Appropriate Delivery of the CRISPR/Cas9 System through the Nonlysosomal Route: Application for Therapeutic Gene Editing

Hang Yin, Xiaoling Yuan, Lihua Luo, +12

Advanced Science