p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, +35

Nature Communications

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Tetsuya Saito, Akiko Kuma, Yuki Sugiura, +16

Nature Communications

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Mami Morita, Taku Sato, Miyuki Nomura, +29

Cancer Cell

Tumor BiologyCell RegulationMedicineCancer BiologyMetabolic Remodeling +6

Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy

Mikko Muona, Ryosuke Ishimura, Anni Laari, +25

The American Journal of Human Genetics

Biallelic VariantsGeneticsNeuroscienceSevere Infantile-onset EncephalopathyNeuropathology +1

Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development

Michael S. Nahorski, Sateesh Maddirevula, Ryosuke Ishimura, +24

Brain

Biallelic Ufm1Brain DevelopmentGeneticsGenomic MechanismDisease Gene Identification +15

Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant

Shun Kageyama, Tetsuya Saito, Miki Obata, +3

Molecular and Cellular Biology

MitophagyMolecular BiologySplicing VariantOxidative StressTranscriptional Regulation +16

An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5

Jessica Huber, Miki Obata, Jens Gruber, +8

Autophagy

Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages

Kenya Kamimura, Yukio Mishima, Miki Obata, +3

Oncogene

Tumor BiologyGenome InstabilityMedicineDna ReplicationDna Replication Stress +7

Predisposition to mouse thymic lymphomas in response to ionizing radiation depends on variant alleles encoding metal-responsive transcription factor-1 (Mtf-1)

Yasushi Tamura, Masaki Maruyama, Yukio Mishima, +8

Oncogene

Variant AllelesImmunogeneticsLymphoid NeoplasiaRadiation BiologyImmunology +8

Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after  -irradiation through Wnt/ -catenin pathway

Akira Sakamaki, Y. Katsuragi, Kichiro Otsuka, +13

Carcinogenesis