Meltem Kacan

Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91phox to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock

Bahar Tunçtan, Belma Korkmaz, Ayse Nihal Sari et al. · Nitric Oxide · 2013 · 63 citations · Full text

Veterinary Medicine, Pathobiology, Pharmacology +17

Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock

Ayse Nihal Sari, Belma Korkmaz, Mehmet Sami Serin et al. · Inflammation Research · 2014 · 29 citations · Full text

Veterinary Medicine, Immunology, Molecular Medicine +17

5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: Contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation

Bahar Tunçtan, Belma Korkmaz, Ayse Nihal Sari et al. · Prostaglandins & Other Lipid Mediators · 2013 · 29 citations · Full text

Veterinary Medicine, Molecular Medicine, Cell Signaling +16

Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats

Ayse Nihal Sari, Meltem Kacan, Demet Unsal et al. · European Journal of Pharmacology · 2013 · 26 citations

Life Sciences, Cell Biology, Pathobiology +16

NS-398 reverses hypotension in endotoxemic rats: Contribution of eicosanoids, NO, and peroxynitrite

Bahar Tunçtan, Ayse Nihal Sari, Meltem Kacan et al. · Prostaglandins & Other Lipid Mediators · 2012 · 18 citations · Full text

Life Sciences, Pharmacology, Physiology +5