Publication | Open Access

5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: Contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation

ImmunologyRenal InflammationCell DeathSeptic ShockCellular PhysiologyInflammationSoluble Epoxide HydrolaseDisease PathophysiologySepsisCell SignalingTissue InjuryMolecular SignalingMolecular PhysiologyImmune FunctionReactive Oxygen Specie20-Hete MimeticCell BiologyCytokinePhysiologyMedicine