Kusma Pyakurel

PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4+ T cell function

Mohamed A. Ghonim, Kusma Pyakurel, Salomè V. Ibba et al. · Journal of Translational Medicine · 2015 · 48 citations · Full text

Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target

Amir A. Al-Khami, Mohamed A. Ghonim, Luis Del Valle et al. · Clinical & Experimental Allergy · 2017 · 48 citations · Full text

DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4+ T-cell function without causing severe combined immunodeficiency

Mohamed A. Ghonim, Kusma Pyakurel, Jihang Ju et al. · Journal of Allergy and Clinical Immunology · 2014 · 44 citations · Full text

Asthma, Primary Immunodeficiency, Cd4+ T-cell Function +10

PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice

Mohamed A. Ghonim, Kusma Pyakurel, Salomè V. Ibba et al. · Clinical Science · 2015 · 37 citations · Full text

Minocycline Blocks Asthma-associated Inflammation in Part by Interfering with the T Cell Receptor-Nuclear Factor κB-GATA-3-IL-4 Axis without a Prominent Effect on Poly(ADP-ribose) Polymerase

Amarjit S. Naura, Hogyoung Kim, Jihang Ju et al. · Journal of Biological Chemistry · 2012 · 28 citations · Full text

Asthma, Immunology, Immune Regulation +16