Mohamed A. Ghonim

Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer

Mohamed A. Ghonim, Salomè V. Ibba, Abdelmetalab Tarhuni et al. · Journal for ImmunoTherapy of Cancer · 2021 · 88 citations · Full text

Medicine, Oncology, Pharmacology +17

Apoptotic DNA Fragmentation May Be a Cooperative Activity between Caspase-activated Deoxyribonuclease and the Poly(ADP-ribose) Polymerase-regulated DNAS1L3, an Endoplasmic Reticulum-localized Endonuclease That Translocates to the Nucleus during Apoptosis

Youssef Errami, Amarjit S. Naura, Hogyoung Kim et al. · Journal of Biological Chemistry · 2012 · 82 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +11

Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target

Amir A. Al-Khami, Mohamed A. Ghonim, Luis Del Valle et al. · Clinical & Experimental Allergy · 2017 · 50 citations · Full text

Life Sciences, Biochemistry, Immunology +17

PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4+ T cell function

Mohamed A. Ghonim, Kusma Pyakurel, Salomè V. Ibba et al. · Journal of Translational Medicine · 2015 · 48 citations · Full text

Medicine, Immunology, Pharmacology +15

DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4+ T-cell function without causing severe combined immunodeficiency

Mohamed A. Ghonim, Kusma Pyakurel, Jihang Ju et al. · Journal of Allergy and Clinical Immunology · 2014 · 44 citations · Full text

Life Sciences, Immunology, Molecular Biology +9