Victoria Sheard

CD3ζ-based chimeric antigen receptors mediate T cell activation via<i>cis</i>- and<i>trans</i>-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

John S. Bridgeman, Kristin Ladell, Victoria Sheard et al. · Clinical & Experimental Immunology · 2013 · 86 citations · Full text

T-regulatory Cell, Immunology, Immunoediting +21

Preclinical Assessment of CAR T-Cell Therapy Targeting the Tumor Antigen 5T4 in Ovarian Cancer

G Owens, Victoria Sheard, Milena Kalaitsidou et al. · Journal of Immunotherapy · 2017 · 56 citations · Full text

T-regulatory Cell, Immunology, Antigen Processing +17

Ligation of the CD2 co-stimulatory receptor enhances IL-2 production from first-generation chimeric antigen receptor T cells

Eleanor J. Cheadle, Dominic G. Rothwell, John S. Bridgeman et al. · Gene Therapy · 2011 · 51 citations

Autoimmune Disease, T-regulatory Cell, Immunology +10

Differential Role of Th1 and Th2 Cytokines in Autotoxicity Driven by CD19-Specific Second-Generation Chimeric Antigen Receptor T Cells in a Mouse Model

Eleanor J. Cheadle, Victoria Sheard, Dominic G. Rothwell et al. · The Journal of Immunology · 2014 · 44 citations

Functional Expression of Secreted Proteins from a Bicistronic Retroviral Cassette Based on Foot-and-Mouth Disease Virus 2A Can Be Position Dependent

Dominic G. Rothwell, Rachel Crossley, John S. Bridgeman et al. · Human Gene Therapy · 2010 · 31 citations