Shing‐Chuan Shen

Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide11Abbreviations: NO, nitric oxide; iNOS, inducible nitricoxide synthase; COX-2, cyclooxygenase-2; PGE2,prostaglandin E2; MTT,3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide, LPS,lipopolysaccharide; NLA, N-nitro-l-arginine; andL-NAME, N-nitro-l-arginine methyl ester.

Yen‐Chou Chen, Shing‐Chuan Shen, Lih-Geeng Chen et al. · Biochemical Pharmacology · 2001 · 270 citations

Life Sciences, Biochemistry, Pharmacology +12

Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase‐2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages

Yen‐Chou Chen, Shing‐Chuan Shen, W. Robert Lee et al. · Journal of Cellular Biochemistry · 2001 · 241 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages

Jyh‐Ming Chow, Shing‐Chuan Shen, Steven K. Huan et al. · Biochemical Pharmacology · 2005 · 239 citations

Life Sciences, Biochemistry, Pharmacology +17

Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production

Yen‐Chou Chen, Shing‐Chuan Shen, W. Robert Lee et al. · Biochemical Pharmacology · 2002 · 229 citations

Life Sciences, Cell Biology, Molecular Biology +15

In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production

Shing‐Chuan Shen, W. Robert Lee, Hui-Yi Lin et al. · European Journal of Pharmacology · 2002 · 227 citations

Medicine, Medicinal Chemistry, Pharmacology +10