Shing‐Chuan Shen

Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide11Abbreviations: NO, nitric oxide; iNOS, inducible nitricoxide synthase; COX-2, cyclooxygenase-2; PGE2,prostaglandin E2; MTT,3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide, LPS,lipopolysaccharide; NLA, N-nitro-l-arginine; andL-NAME, N-nitro-l-arginine methyl ester.

Yen‐Chou Chen, Shing‐Chuan Shen, Lih-Geeng Chen et al. · Biochemical Pharmacology · 2001 · 270 citations

Inhibitory Activity, Medicinal Chemistry, Biochemistry +12

Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages

Jyh‐Ming Chow, Shing‐Chuan Shen, Steven K. Huan et al. · Biochemical Pharmacology · 2005 · 237 citations

Inflammation, Heme Oxygenase 1, H2o2-induced Apoptosis +11

Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production

Yen‐Chou Chen, Shing‐Chuan Shen, W. Robert Lee et al. · Biochemical Pharmacology · 2002 · 227 citations

Inflammation, Reductive Stress, Lipid Peroxidation +12

In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production

Shing‐Chuan Shen, W. Robert Lee, Hui-Yi Lin et al. · European Journal of Pharmacology · 2002 · 226 citations

Biochemistry, Reactive Nitrogen Specie, Medicine +9

Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca2+-dependent endonuclease

W. Robert Lee, Shing‐Chuan Shen, Hui-Yi Lin et al. · Biochemical Pharmacology · 2002 · 220 citations

Signal Transduction, Reactive Oxygen Species, Oxysterol +11