A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

Donal Skelly, Edel Hennessy, Marc‐André Dansereau, +1

PLoS ONE

Systemic LpsImmunologyImmune RegulationRenal InflammationImmune System +25

Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL‐1β drives amplified responses in primed astrocytes and neuronal network dysfunction

Ana Belén López-Rodríguez, Edel Hennessy, Carol Murray, +13

Alzheimer s & Dementia

Acute Systemic InflammationImmunologyNeuroinflammationInflammationAlzheimer's Disease +14

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

Colm Cunningham, Edel Hennessy

Alzheimer s Research & Therapy

Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α

Edel Hennessy, Éadaoin W. Griffin, Colm Cunningham

Journal of Neuroscience

ImmunologyImmune RegulationCell DeathCell Infiltration ResponsesSocial Sciences +15

Worsening Cognitive Impairment and Neurodegenerative Pathology Progressively Increase Risk for Delirium

Daniel Davis, Donal Skelly, Carol Murray, +11

American Journal of Geriatric Psychiatry

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

Arshed Nazmi, Robert H. Field, Éadaoin W. Griffin, +11

Glia

Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration

Edel Hennessy, S. Gormley, Ana Belén López-Rodríguez, +3

Brain Behavior and Immunity

Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease

Claire McDonald, Edel Hennessy, Ana Rubio‐Araiz, +5

Brain Behavior and Immunity

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineImmunologyCell Death +12

Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

Donal Skelly, Éadaoin W. Griffin, Carol Murray, +9

Molecular Psychiatry

Correction: A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

Donal Skelly, Edel Hennessy, Marc‐André Dansereau, +1

PLoS ONE