Brain glycogen serves as a critical glucosamine cache required for protein glycosylation

Ramon C. Sun, Lyndsay E.A. Young, Ronald C. Bruntz, +30

Cell Metabolism

Protein GlycosylationBiochemistryMedicineNatural SciencesGlycobiology +7

Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion

M. Kathryn Brewer, Annette Uittenbogaard, Grant L. Austin, +16

Cell Metabolism

Structural Mechanism of Laforin Function in Glycogen Dephosphorylation and Lafora Disease

Madushi Raththagala, M. Kathryn Brewer, Matthew W. Parker, +18

Molecular Cell

Protein FunctionSignal TransductionBiochemistryLaforin FunctionNatural Sciences +5

Calpain 5 Is Highly Expressed in the Central Nervous System (CNS), Carries Dual Nuclear Localization Signals, and Is Associated with Nuclear Promyelocytic Leukemia Protein Bodies

Ranjana Singh, M. Kathryn Brewer, Charles Mashburn, +4

Journal of Biological Chemistry

Molecular NeuroscienceSignal TransductionNeuroscienceCalpain 5Central Nervous System +8

Polyglucosan body structure in Lafora disease

M. Kathryn Brewer, Jean‐Luc Putaux, Alberto Rondon, +3

Carbohydrate Polymers

HistopathologyPathologyGeneral PathologyAnatomyMedicine +2

Lack of Astrocytic Glycogen Alters Synaptic Plasticity but Not Seizure Susceptibility

Jordi Durán, M. Kathryn Brewer, Arnau Hervera, +4

Molecular Neurobiology

Synaptic PlasticitySeizure SusceptibilityNeurophysiologyNeurological FunctionNeurology +5

A novel EPM2A mutation yields a slow progression form of Lafora disease

Maria Adelaida García-Gimeno, Pilar Natalia Rodilla-Ramírez, Rosa Viana, +4

Epilepsy Research

GeneticsPathogenesisPathologyMolecular GeneticsLafora Disease +3

An empirical pipeline for personalized diagnosis of Lafora disease mutations

M. Kathryn Brewer, María Machío-Castello, Rosa Viana, +10

iScience

Lack of p62 Impairs Glycogen Aggregation and Exacerbates Pathology in a Mouse Model of Myoclonic Epilepsy of Lafora

Pasquale Pellegrini, Arnau Hervera, Olga Varea, +8

Molecular Neurobiology

Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis

M. Kathryn Brewer, Pascual Torres, Victòria Ayala, +7

Journal of Neurochemistry