A non‐enzymatic function of 17β‐hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival

Katharina Rauschenberger, Katja Schöler, Jörn Oliver Sass, +26

EMBO Molecular Medicine

Expanded substrate screenings of human and Drosophila type 10 17β-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3α/7α/7β/17β/20β/21-HSD

N. Shafqat, Hanns–Ulrich Marschall, Charlotta Filling, +8

Biochemical Journal

GeneticsHormone MetabolismCholic AcidOxidative StressMetabolic Syndrome +17

Crystal Structures of Human HMG-CoA Synthase Isoforms Provide Insights into Inherited Ketogenesis Disorders and Inhibitor Design

N. Shafqat, A.P. Turnbull, Johannes Zschocke, +2

Journal of Molecular Biology

Inhibitor DesignBiochemistryBiomolecular Structure PredictionNatural SciencesInherited Ketogenesis Disorders +4

Human and rodent type 1 11�-hydroxysteroid dehydrogenases are 7�-hydroxycholesterol dehydrogenases involved in oxysterol metabolism

G. Tomas M. Hult, Björn Elleby, N. Shafqat, +5

Cellular and Molecular Life Sciences

OxysterolAldehyde DehydrogenaseBiochemistryPhysiologyRodent Type 1 +10

Three-dimensional Structure and Enzymatic Function of Proapoptotic Human p53-inducible Quinone Oxidoreductase PIG3

Sergio Porté, Eva Valencia, Evgenia A Yakovtseva, +8

Journal of Biological Chemistry

Insight into <i>S</i>-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits

N. Shafqat, J.R.C. Muniz, Ewa S. Pilka, +4

Biochemical Journal

Sdr Sub-familyBiosynthesisBiological MethylationCellular EnzymologyBiochemistry +11

Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue

N. Shafqat, Jawed Shafqat, Guenther Eissner, +7

Cellular and Molecular Life Sciences

Nadph-dependent Dicarbonyl ReductaseAldehyde DehydrogenaseBiochemistryEndothelial DysfunctionMetabolic Regulation +9

Active site variability of type 1 11β-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons

Malin Hult, N. Shafqat, Björn Elleby, +7

Molecular and Cellular Endocrinology

Type 1BiochemistryCross-species ComparisonsActive Site VariabilityPharmacology +2

Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure–activity relationships

C. Bhatia, Stephanie Oerum, James E. Bray, +4

Chemico-Biological Interactions

Human Short-chain Dehydrogenases/reductasesAldo-keto ReductaseAldehyde DehydrogenaseBiochemistryNatural Sciences +6

A structural mapping of mutations causing succinyl‐CoA:3‐ketoacid CoA transferase (SCOT) deficiency

N. Shafqat, K.L. Kavanagh, Jörn Oliver Sass, +5

Journal of Inherited Metabolic Disease