Lara A. Gruijs da Silva

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation

Lara A. Gruijs da Silva, Francesca Simonetti, Saskia Hutten et al. · The EMBO Journal · 2022 · 179 citations · Full text

TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury

Alessandro Zambusi, Klara Tereza Novoselc, Saskia Hutten et al. · Nature Neuroscience · 2022 · 55 citations

Inflammation, Traumatic Brain Injury, Neuroregeneration +14

Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo

Henrick Riemenschneider, Francesca Simonetti, Udit Sheth et al. · Acta Neuropathologica Communications · 2023 · 27 citations · Full text

Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation

Lara A. Gruijs da Silva, Francesca Simonetti, Saskia Hutten et al. · 2021 · 24 citations · Full text

Molecular Biology, Cell Death, Neurochemical Biomarkers +16

The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis

Julia Zibold, Lola Lessard, Flavien Picard et al. · Brain · 2023 · 12 citations · Full text

Neurodegenerative Diseases, Patient Muscle Tissue, Amyotrophic Lateral Sclerosis +14