Herbert G. Kasler

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Anthony J. Covarrubias, Abhijit Kale, Rosalba Perrone et al. · Nature Metabolism · 2020 · 380 citations · Full text

Inflammation, Cd38+ Macrophages, Aging +11

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

Azar Asadi Shahmirzadi, Daniel Edgar, Chen‐Yu Liao et al. · Cell Metabolism · 2020 · 374 citations · Full text

Lifespan Extension, Aging, Endogenous Metabolite +13

ERK5 Is a Novel Type of Mitogen-Activated Protein Kinase Containing a Transcriptional Activation Domain

Herbert G. Kasler, Joseph Victoria, Omar Duramad et al. · Molecular and Cellular Biology · 2000 · 267 citations · Full text

Immunology, Cell Death, Transcriptional Regulation +19

HDAC7, a Thymus-Specific Class II Histone Deacetylase, Regulates Nur77 Transcription and TCR-Mediated Apoptosis

Herbert G. Kasler, Wolfgang Fischle, Véronique Kiermer et al. · Immunity · 2003 · 203 citations · Full text

Chromatin, Transcriptional Regulation, Cell Regulation +12

SIRT1 deacetylates RORγt and enhances Th17 cell generation

Hyung W. Lim, Seung Goo Kang, Jae Kyu Ryu et al. · The Journal of Experimental Medicine · 2015 · 147 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +25