Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9

Gözde Korkmaz, Rui Lopes, Alejandro P. Ugalde, +6

Nature Biotechnology

Enhancer ElementsEngineeringCell ModificationFunctional Genetic ScreensGenetics +10

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

Fabricio Loayza‐Puch, Koos Rooijers, Levi C.M. Buil, +10

Nature

Tumor BiologyTumour-specific Proline VulnerabilityMedicinePathologyProteomics +3

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

Nicolas Léveillé, Carlos A. Melo, Koos Rooijers, +13

Nature Communications

p53 induces transcriptional and translational programs to suppress cell proliferation and growth

Fabricio Loayza‐Puch, Jarno Drost, Koos Rooijers, +3

Genome biology

PAX8 and MECOM are interaction partners driving ovarian cancer

Melusine Bleu, Fanny Mermet‐Meillon, Verena Apfel, +36

Nature Communications

PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

Melusine Bleu, Swann Gaulis, Rui Lopes, +16

Nature Communications

E-Cadherin Destabilization Accounts for the Pathogenicity of Missense Mutations in Hereditary Diffuse Gastric Cancer

Joana Simões‐Correia, Joana Figueiredo, Rui Lopes, +4

PLoS ONE

Missense MutationsTissue ArchitectureHdgc PatientsTumor HeterogeneityMedicine +10

LncRNA-OIS1 regulates DPP4 activation to modulate senescence induced by RAS

Li Li, Pieter C. Van Breugel, Fabricio Loayza‐Puch, +17

Nucleic Acids Research

Oncogene-induced SenescenceRadiation OncologyDevelopmental BiologyCell RegulationMedicine +12

Myc coordinates transcription and translation to enhance transformation and suppress invasiveness

Ran Elkon, Fabricio Loayza‐Puch, Gözde Korkmaz, +8

EMBO Reports

GRO-seq, A Tool for Identification of Transcripts Regulating Gene Expression

Rui Lopes, Reuven Agami, Gözde Korkmaz

Methods in molecular biology

Transcriptional RegulationFunctional GenomicsA ToolGene Sequence AnnotationNatural Sciences +10