Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice.

Toshimasa Tsujinaka, Junya Fujita, Chikara Ebisui, +8

Journal of Clinical Investigation

Muscle FunctionImmunologyImmune RegulationCell DeathMil-6r Antibody +23

Interleukin-6 Induces Proteolysis by Activating Intracellular Proteases (Cathepsins B and L, Proteasome) in C2C12 Myotubes

Chikara Ebisui, Toshimasa Tsujinaka, Takashi Morimoto, +6

Clinical Science

Muscle Undergoes Atrophy in Association with Increase of Lysosomal Cathepsin Activity in Interleukin-6 Transgenic Mouse

Toshimasa Tsujinaka, Chikara Ebisui, Junya Fujita, +7

Biochemical and Biophysical Research Communications

InflammationMuscle FunctionMolecular PhysiologyMuscle InjuryDisease Mechanism +12

Anti-interleukin-6 receptor antibody prevents muscle atrophy in colon-26 adenocarcinoma-bearing mice with modulation of lysosomal and ATP-ubiquitin-dependent proteolytic pathways

Junya Fujita, Toshimasa Tsujinaka, Masahiko Jano, +7

International Journal of Cancer

CYP1A1 CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus

Shunji Morita, Masahiko Yano, Hitoshi Shiozaki, +13

International Journal of Cancer

Cyp1a1 Cyp2e1Squamous-cell CarcinomaEpidemiologyEsophageal Cancer PatientsEsophageal Cancer +12

Multicenter prospective trial of total gastrectomy versus proximal gastrectomy for upper third cT1 gastric cancer

Makoto Yamasaki, Shuji Takiguchi, Takeshi Omori, +25

Gastric Cancer

Surgical OncologyGastrointestinal OncologyMedicineGastroenterologyMulticenter Prospective Trial +4

Prognostic Impact of Major Receptor Tyrosine Kinase Expression in Gastric Cancer

Yukinori Kurokawa, Nariaki Matsuura∥, Ryohei Kawabata, +9

Annals of Surgical Oncology

Prognostic ImpactMedicineReceptor Tyrosine KinaseGastroenterologyPathology +8

Role of intracellular proteases in differentiation of L6 myoblast cells.

Chikara Ebisui, Toshimasa Tsujinaka, Yasutoshi Kido, +5

PubMed

Cellular PhysiologyProtein ExpressionB. CalpainIntracellular ProteasesCell Signaling +14

Changes of Proteasomes and Cathepsins Activities and Their Expression during Differentiation of C2C12 Myoblasts

Chikara Ebisui, Toshimasa Tsujinaka, Takashi Morimoto, +6

The Journal of Biochemistry

Role of Interleukin-6 in Skeletal Muscle Protein Breakdown and Cathepsin Activity in vivo

Junya Fujita, Toshimasa Tsujinaka, Chikara Ebisui, +5

European Surgical Research

Muscle FunctionImmunologyCell DeathCellular PhysiologyInflammation +18