Replication fork reversal triggers fork degradation in BRCA2-defective cells

Sofija Mijic, Ralph Zellweger, Nagaraja Chappidi, +8

Nature Communications

Genome InstabilityReversed Replication ForksReplication ForksChromatin RemodelingNatural Sciences +11

Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness

Hitoshi Takizawa, Kristin Fritsch, Larisa V. Kovtonyuk, +10

Cell stem cell

InflammationT-regulatory CellInnate Immune SystemImmunologyHematopoietic Stem Cells +5

Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL

Há Thi Nguyen, Mieke Geens, Afroditi Mertzanidou, +4

Molecular Human Reproduction

GeneticsAdult Stem CellIncreased ExpressionMutant CellsTranscriptional Regulation +18

Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability

Kurt Jacobs, Filippo Zambelli, Afroditi Mertzanidou, +6

Stem Cell Reports

Chromosomal meiotic segregation, embryonic developmental kinetics and DNA (hydroxy)methylation analysis consolidate the safety of human oocyte vitrification

N De Munck, Laetitia Petrussa, Greta Verheyen, +8

Molecular Human Reproduction

OocyteFertilityGeneticsHuman Oocyte VitrificationPreimplantation Genetic Testing +18

Chromosome constitution of human embryos generated after in vitro maturation including 3-isobutyl-1-methylxanthine in the oocyte collection medium

Claudia Spits, Luis Guzmán, Afroditi Mertzanidou, +7

Human Reproduction

Low-grade chromosomal mosaicism in human somatic and embryonic stem cell populations

Kurt Jacobs, Afroditi Mertzanidou, Mieke Geens, +3

Nature Communications

ChromatinSomatic Cell GeneticsGeneticsStem Cell ResearchLow-grade Chromosomal Mosaicism +5

Mitotic spindle disruption in human preimplantation embryos activates the spindle assembly checkpoint but not apoptosis until Day 5 of development

Kurt Jacobs, H. Van de Velde, C. De Paepe, +2

Molecular Human Reproduction

Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming

Kurt Jacobs, Cyril Doerdelmann, Jana Krietsch, +13

Molecular Cell

MedicineStem Cell MobilizationHematologyPrimpol-mediated ReprimingCell Transplantation +5

MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice

Marc E. Healy, Yannick Boege, Michael C. Hodder, +31

Gastroenterology