DJ‐1 has a role in antioxidative stress to prevent cell death

Takahiro Taira, Yoshiro Saito, Takeshi Niki, +3

EMBO Reports

Redox SignalingAntioxidative StressApoptosisImmunologyCell Death +6

DJ-1, a Novel Oncogene Which Transforms Mouse NIH3T3 Cells in Cooperation withras

Daisuke Nagakubo, Takahiro Taira, Hirotake Kitaura, +4

Biochemical and Biophysical Research Communications

Knockout MouseMedicineMolecular BiologyCooperation WithrasCell Engineering +2

Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells

Tomoya Kinumi, Junko Kimata, Takahiro Taira, +2

Biochemical and Biophysical Research Communications

Redox SignalingBiochemistrySensitive Cysteine ResidueNatural SciencesLipid Peroxidation +9

DJ-1 Positively Regulates the Androgen Receptor by Impairing the Binding of PIASxα to the Receptor

Kazuko Takahashi, Takahiro Taira, Takeshi Niki, +3

Journal of Biological Chemistry

Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4‐phenylbutyrate, a chemical chaperone

Masatoshi Inden, Yoshihisa Kitamura, Hiroki Takeuchi, +9

Journal of Neurochemistry

Experimental PharmacologyOxidative StressChemical ChaperoneAlzheimer's DiseaseNeurology +14

The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease

Kazuya Honbou, Nobuo Suzuki, Masataka Horiuchi, +4

Journal of Biological Chemistry

DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.

Takeshi Niki, Kazuko Takahashi-Niki, Takahiro Taira, +2

PubMed

Androgen ReceptorGeneticsMolecular BiologyEpigeneticsDjbp-hdac Complex +16

DJ-1 binds to mitochondrial complex I and maintains its activity

Takuya Hayashi, Chikako Ishimori, Kazuko Takahashi-Niki, +6

Biochemical and Biophysical Research Communications

Signal TransductionMitochondrial FunctionMitochondrial DynamicNatural SciencesMolecular Biology +8

Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities

Yumi Shinbo, Teruo Niki, Takahiro Taira, +6

Cell Death and Differentiation

KinesiologyProper Sumo-1 ConjugationMolecular BiologySystems BiologyFull Activities

PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model

Masatoshi Inden, Takahiro Taira, Yoshihisa Kitamura, +13

Neurobiology of Disease

Neurodegenerative DiseasesNeurobiology Of DiseaseDisease Rat ModelNeuropharmacologyDegenerative Pathology +11