Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

Elliot D. Mock, Mohammed Ahmed Mustafa, Ozge Gunduz‐Cinar, +35

Nature Chemical Biology

Knockout MouseEmotional BehaviorBehavioral NeuroscienceMedicineBehavioral Pharmacology +10

Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults

Francisco J. Osuna‐Prieto, Borja Martínez‐Téllez, Lourdes Ortiz-Alvarez, +15

Cardiovascular Diabetology

A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence

Ming Jiang, Mirjam Huizenga, Jonah L. Wirt, +26

Nature Communications

Omega‐6 and omega‐3 oxylipins as potential markers of cardiometabolic risk in young adults

Lucas Jurado‐Fasoli, Xinyu Di, Isabelle Köhler, +10

Obesity

Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial

Lucas Jurado‐Fasoli, Xinyu Di, Guillermo Sánchez‐Delgado, +13

EBioMedicine

Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells

Annelot C. M. van Esbroeck, Vasudev Kantae, Xinyu Di, +10

Frontiers in Molecular Neuroscience

Proteinlipid InteractionDiacylglycerol LipaseRetinoic AcidMag Lipase ActivityRa Stimulation +15

Plasma Levels of Bile Acids Are Related to Cardiometabolic Risk Factors in Young Adults

Francisco J. Osuna‐Prieto, José Rubio‐López, Xinyu Di, +5

The Journal of Clinical Endocrinology & Metabolism

A comprehensive UHPLC-MS/MS method for metabolomics profiling of signaling lipids: Markers of oxidative stress, immunity and inflammation

Wei Yang, Johannes C. Schoeman, Xinyu Di, +3

Analytica Chimica Acta

Activity-based protein profiling of the human failing ischemic heart reveals alterations in hydrolase activities involving the endocannabinoid system

Annelot C. M. van Esbroeck, Zoltán V. Varga, Xinyu Di, +9

Pharmacological Research

Cannabis UseEndocannabinoid SystemBiochemistryFunctional SelectivityMedicine +9

Structure–Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family

Juan Zhou, Elliot D. Mock, Karol Al Ayed, +15

Journal of Medicinal Chemistry