Satoru Noji

Benzimidazole Derivatives Bearing Substituted Biphenyls as Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase Inhibitors:  Structure−Activity Relationship Studies and Identification of a Potent and Highly Selective Inhibitor JTK-109

Shintaro Hirashima, Takayoshi Suzuki, Tomio Ishida et al. · Journal of Medicinal Chemistry · 2006 · 146 citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Bioorganic Chemistry +15

Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors

Kazutaka Ikegashira, Takahiro Oka, Shintaro Hirashima et al. · Journal of Medicinal Chemistry · 2006 · 110 citations · Full text

Combinatorial Chemistry, Biochemistry, Medicine +11

Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo

Atsuo Tanimoto, Yoshihiro Ogawa, Chika Oki et al. · Inflammation Research · 2014 · 99 citations · Full text

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders

Satoru Noji, Yoshinori Hara, Tomoya Miura et al. · Journal of Medicinal Chemistry · 2020 · 52 citations · Full text

Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: Benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety

Shintaro Hirashima, Takahiro Oka, Kazutaka Ikegashira et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 37 citations

Biochemistry, 2-Morpholinophenyl Moiety, Natural Sciences +8