The First Synthesis of a Daphnane Diterpene:  The Enantiocontrolled Total Synthesis of (+)-Resiniferatoxin

Paul A. Wender, Cynthia D. Jesudason, Hiroyuki Nakahira, +3

Journal of the American Chemical Society

Bioorganic ChemistryEngineeringAltmetric Attention ScoreOrganic ChemistryChemistry +15

Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models

Rachel I. Anderson, Howard C. Becker, Benjamin L. Adams, +2

Frontiers in Neuroscience

Substance UseOrexin-2 Receptor AntagonistsPharmacotherapyExperimental PharmacologyAlcohol Misuse +17

First-in-Human Assessment of ¹¹C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer

Mika Naganawa, Nabeel Nabulsi, Shannan Henry, +13

Journal of Nuclear Medicine

Potent oxindole based human β3 adrenergic receptor agonists

Frits C. Stevens, William E. Bloomquist, Anthony G. Borel, +7

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinePhysiologyMechanism Of ActionPharmacological Agent +5

Synthesis and SAR of novel histamine H3 receptor antagonists

Cynthia D. Jesudason, Lisa S. Beavers, Jeffrey W. Cramer, +12

Bioorganic & Medicinal Chemistry Letters

MedicineMechanism Of ActionPharmacological AgentPharmacotherapyPharmacology +1

Evaluation of a PET Radioligand to Image <i>O</i>-GlcNAcase in Brain and Periphery of Rhesus Monkey and Knock-Out Mouse

Soumen Paul, Mohammad B. Haskali, Jeih-San Liow, +16

Journal of Nuclear Medicine

Whole-body ImagingPet RadioligandAlzheimer's DiseaseDegenerative PathologyRadiopharmaceutical Therapy +16

LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy

Thomas Fitch, Mark J. Benvenga, Cynthia D. Jesudason, +5

Frontiers in Neuroscience

Selective Orexin-2PharmacotherapyAnimal Model PredictiveExperimental PharmacologyOxidative Stress +15

PET ligands [ ¹⁸ F]LSN3316612 and [ ¹¹ C]LSN3316612 quantify <i>O</i> -linked-β- <i>N</i> -acetyl-glucosamine hydrolase in the brain

Shuiyu Lu, Mohammad B. Haskali, Kevin M. Ruley, +24

Science Translational Medicine

Evaluation of¹¹C-LSN3172176 as a Novel PET Tracer for Imaging M₁Muscarinic Acetylcholine Receptors in Nonhuman Primates

Nabeel Nabulsi, Daniel Holden, Ming‐Qiang Zheng, +15

Journal of Nuclear Medicine

The synthesis of substituted aryl diazirines. A bifunctional reagent suitable for application to photoaffinity labelling studies.

Jack E. Baldwin, Cynthia D. Jesudason, Mark G. Moloney, +2

Tetrahedron

Photoredox ProcessPhotochemistrySubstituted Aryl DiazirinesBifunctional Reagent SuitableSynthetic Photochemistry +3