In this contribution, we describe a novel modeling approach to predicting retention times (t_r) in comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC × GC-ToF-MS) with a particular emphasis on the second-dimension (²D) retention time predictions (²t_r). This approach is referred to as a "top-down" approach in that it breaks down the complete GC × GC separation into two independent one-dimensional gas chromatography separations (1D-GC). In this regard, both dimensions, that is, first dimension (¹D) and second dimension (²D) are treated separately, and the cryogenic modulator is simply considered as a second consecutive injection device. Separate 1D-GC t_r predictions are performed on both dimensions using the same flow rate as the one deployed in the conventional GC × GC system. The separate t_r predictions are then combined to account for the two-dimensional separation. This model was applied to 24 analytes from 2 standard mixtures (Grob Test Mix and Fragrance Materials Test Mix) and assessed across 9 GC × GC chromatographic conditions. The experimental and predicted chromatographic retention space occupations were assessed by using the convex hull approach defined by the Delaunay triangulation. The predicted percentage of space occupation corresponded favorably with the experimental values. Furthermore, the top-down approach enabled an accurate prediction of the ²t_r of all investigated analytes, providing an average ²t_r modeling error of 0.26 ± 0.01 s.

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