Dendritic Degeneration, Neurovascular Defects, and Inflammation Precede Neuronal Loss in a Mouse Model for Tau-Mediated Neurodegeneration

Tomasz Jaworski, Benoit Lechat, David Demedts, +7

American Journal Of Pathology

InflammationNeurodegenerative DiseasesAlzheimer's DiseaseMedicineImmunology +12

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease

Bart Van Gool, Steffen E. Storck, Sara Reekmans, +5

Molecular Neurobiology

AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice

Tomasz Jaworski, Ilse Dewachter, Benoit Lechat, +9

PLoS ONE

Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3

Linde De Troyer, Peihua Zhao, Tibor J. Pastor, +10

Nucleic Acids Research

Factor Sart3Transcriptional RegulationSystems BiologyCore Splicing MachineryRna Splicing +10

GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine Morphology

Ilona Kondratiuk, Szymon Łęski, Małgorzata Urbańska, +6

Molecular Neurobiology

Dendritic BiologyMmp InhibitionSynaptic TransmissionStructural PlasticityCellular Neurobiology +24

Early Structural and Functional Defects in Synapses and Myelinated Axons in Stratum Lacunosum Moleculare in Two Preclinical Models for Tauopathy

Hervé Maurin, Seon‐Ah Chong, Igor Kraev, +9

PLoS ONE

Early StructuralStratum Lacunosum MoleculareSynaptic TransmissionMolecular BiologyFunctional Defects +24

Tauopathy Differentially Affects Cell Adhesion Molecules in Mouse Brain: Early Down-Regulation of Nectin-3 in Stratum Lacunosum Moleculare

Hervé Maurin, Claire M. Seymour, Benoit Lechat, +6

PLoS ONE

Stratum Lacunosum MoleculareImmunologyCell Adhesion MoleculesNeurochemical BiomarkersAmyloid Accumulation +17

Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain

Jan R. Detrez, Hervé Maurin, Kristof Van Kolen, +10

Neurobiology of Disease

Knockout MouseDevelopmental BiologyNeurophysiologyNeuroanatomyRegional Vulnerability +6

Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase

Hervé Maurin, Benoit Lechat, Ilse Dewachter, +6

Molecular Brain

Syntenin-knock out reduces exosome turnover and viral transduction

Rudra Kashyap, Marielle Balzano, Benoit Lechat, +9

Scientific Reports